December 3, 2020
musagenomics

Advances in gene therapy for hematologic

Advances in gene therapy for hematologic disease and considerations for transfusion medicine

As the list of regulatory agency-approved gene therapies grows, these products are now in the therapeutic spotlight with the potential to cure or dramatically alleviate several benign and malignant hematologic diseases. The mechanisms for gene manipulation are diverse, and include the use of a variety of cell sources and both viral vector- and nuclease-based targeted approaches.
Gene editing has also reached the realm of blood component therapy and testing, where cultured products are being developed to improve transfusion support for individuals with rare blood types. In this review, we summarize the milestones in the development of gene therapies for hematologic diseases, mechanisms for gene manipulation, and implications for transfusion medicine and blood centers as these therapies continue to advance and grow.
musagenomics
musagenomics

Protein (antigen/antibodies) Biotinylation Kit

80300 1 kit
EUR 445.00

Anti-HMGB1 Peptide (2-11) Antibodies

7029 1 mg/ml x 0.1 ml
EUR 338.55
Description: Anti-HMGB1 Peptide (2-11) Antibodies

Anti-HMGB1 Peptide (166-176) Antibodies

7030 1 mg/ml x 0.1 ml
EUR 338.55
Description: Anti-HMGB1 Peptide (166-176) Antibodies

Human anti-acrosin antibodies,ACR ELISA Kit

201-12-1857 96 tests
EUR 440.00
  • This anti-acrosin antibodies ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human anti-prothrombins antibodies,aPT1/aPT2 ELISA Kit

201-12-0498 96 tests
EUR 440.00
  • This anti-prothrombins antibodies ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human anti-platelet antibodies,PA-Ab ELISA Kit

201-12-2178 96 tests
EUR 440.00
  • This anti-platelet antibodies ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Protein (antigen/antibodies) Biotinylation detection/quantitation ELISA Kit

80310 1 kit
EUR 590.00

Humna anti-sperm protein 17 antibodies,Sp17 ELISA Kit

201-12-1840 96 tests
EUR 440.00
  • This Humna anti-sperm protein 17 antibodies ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Western blot Kit for Rabbit Primary Antibodies, Chemilum. Substrate

80200-Rb 1 kit
EUR 651.00

Western blot Kit for Goat Primary Antibodies, Chemilum. Substrate

80201-Gt 1 kit
EUR 651.00

Western blot Kit for Mouse Primary Antibodies, Chemilum. Substrate

80202-Mo 1 kit
EUR 651.00

Western blot Kit for Rat Primary Antibodies, Chemilum. Substrate

80203-Rt 1 kit
EUR 651.00

Western blot Kit for Chicken Primary Antibodies, Chemilum. Substrate

80204-Ch 1 kit
EUR 651.00

Western blot Kit for Monkey Primary Antibodies, Chemilum. Substrate

80205-Mk 1 kit
EUR 651.00

Western blot Kit for Human Primary Antibodies, Chemilum. Substrate

80207-Hu 1 kit
EUR 651.00

Western blot Kit for Sheep Primary Antibodies; Chemilum. Substrate

80208-Sh 1 kit
EUR 651.00

Western blot Kit for Pig Primary Antibodies; Chemilum. Substrate

80209-Pg 1 kit
EUR 651.00

Rabbit Anti-Plasmodium falciparum Histone antibodies IgG (aff pure)

AB-23103-A 100ug
EUR 482.00

Western blot Kit for G. pig Primary Antibodies, Chemilum. Substrate

80206-Gp 1 kit
EUR 651.00

Human Anti-Nuclear Antibodies (ANA) ELISA Kit, 96 tests, Semi-Quantitative

3205 1 kit
EUR 651.00

Horseradish peroxidase (HRP) conjugation kit for antigen/antibodies (1x 2 mg)

80220 1 Kit
EUR 445.00

Human platelet antibodies IgG/M/A,PA-IgG/M/A ELISA Kit

201-12-0518 96 tests
EUR 440.00
  • This platelet antibodies IgG/M/A ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Custom Testing of Sample for Human Anti-Mouse Antibodies (HAMA) by ELISA

200-205-CUX Custom Ask for price

Custom Testing of Samples for Antibodies to Human Adenovirus (hAd5 hxn) by ELISA

950-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Rabies Vaccines by ELISA

600-020-CUX Custom Ask for price

Custom ELISA testing for anthrax antibodies in animal and human samples (vaccinated or normal)

900-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies to Anthrax Proteins (PA83/LF/EF) by ELISA

800-100-CUX Custom Ask for price

Horseradish peroxidase (HRP) conjugation kit for antigen/antibodies (Micro; 3 x 200 ug HRP)

80225 1 kit
EUR 445.00

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Measles/Rubeola vaccines by ELISA

530-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Chikungunya virus (CHIKV) by ELISA

530-400-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Ovalbumin (Gal d2) by ELISA

670-140-CUX Custom Ask for price

Custom Testing of Samples for Antibodies Snake Venom (anti-venins from Horse/Sheep) by ELISA

570-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Diphtheria Toxin/Toxoid by ELISA

940-090-CUX Custom Ask for price

TruStrip RDT 5-Minute rapid test to confirm the presence of humanized antibodies, 10 tests/pk

1750-RDT-10 1 kit
EUR 354.00

Human Anti-Daclizumab (Zenapax) IgG (Anti-drug antibodies/ADA) ELISA Kit for human, 96 tests, quantitative

210-310-ADG 1 kit
EUR 1138.00

Human Anti-Basiliximab (Simulect) IgG (Anti-drug antibodies/ADA) ELISA Kit for human, 96 tests, quantitative

210-330-ABG 1 kit
EUR 1138.00

Human Anti-Eculizumab (Soliris) IgG (Anti-drug antibodies/ADA) ELISA Kit for human, 96 tests, quantitative

210-410-AEG 1 Kit
EUR 1138.00

Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgG ELISA Kit, 96 tests, Quantitative

680-500-ASG 1 Kit
EUR 712.00

Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgM ELISA Kit, 96 tests, Quantitative

680-505-ASM 1 kit
EUR 712.00

Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgA ELISA Kit, 96 tests, Quantitative

680-510-ASA 1 kit
EUR 712.00

Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgG ELISA Kit, 96 tests, Quantitative

680-520-ASG 1 kit
EUR 712.00

Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgM ELISA Kit, 96 tests, Quantitative

680-525-ASM 1 kit
EUR 712.00

Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgA ELISA Kit, 96 tests, Quantitative

680-530-ASA 1 kit
EUR 712.00

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Influenza A virus vaccines by ELISA

920-040-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Tetanus vaccines (Toxin/Toxoid) by ELISA

930-090-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Cholera Toxins (A/B) by ELISA

945-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to S. enterica serovar Typhi (Typhoid) by ELISA

990-500-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Varicella Zoster Virus (VZV/chickenpox) vaccine by ELISA

520-200-CUX Custom Ask for price

Human Anti-Erbitux (Cetuximab/C225/IMC225) IgG (Anti-drug antibodies/ADA) ELISA Kit for human, 96 tests, quantitative

210-110-AEG 1 kit
EUR 1138.00

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to S. Pneumococcal vaccines (Penumovax/Prevanr/Synflroix) by ELISA

560-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Human Anti-Keyhole limpet hemocyanin (KLH) by ELISA

700-140-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Schistosoma mansoni vaccine (Smp-80/GST) by ELISA

960-190-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Respiratory syncytial virus (RSV) vaccine (RSV-F) by ELISA

510-190-CUX Custom Ask for price

Human Anti-Remicade (Infliximab/Infimab/Remsima/Inflectra) IgG (Anti-drug antibodies/ADA) ELISA Kit for human, 96 tests, quantitative

200-350-ARG 1 Kit
EUR 1138.00

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Meninigitis Vaccines (Group A/C/Y/W) by ELISA

600-300-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Mumps/Parotitis Virus vaccines bVaccine ELISAs for human diseases ELISA

520-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Yellow Fever Virus (YFV) vaccine (ENV/prM/NS1) by ELISA

530-200-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Dengue Virus proteins (DV1-4, Env/prM/NS1) by ELISA

540-100-CUX Custom Ask for price

Human Anti-Ipilimumab (Yervoy/MDX-010/MDX-101) IgG (Anti-drug antibodies/ADA) ELISA Kit for human, 96 tests, quantitative

210-210-AIG 1 kit
EUR 1138.00

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Meninigitis B Vaccine Proteins (NadA/fHBP/NHBA/PorA) by ELISA

600-900-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to H. Influenzae B Vaccines (polyribosyl phosphate (Hib-PRP) by ELISA

980-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Cytomegalovirus (HCMV/CMV/Human Herpes Virus-5/HHV-5) by ELISA

3300-370-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Human Anti-Japanese encephalitis virus envelop Protein (JEV-EP) by ELISA

910-110-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to West Nile Virus vaccines (WNV-ENV/NS1/prM) vaccine by ELISA

910-360-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Human Anti-Influenza A virus M2 Protein (universal vaccine) by ELISA

920-200-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Tick Borne Encephalitis Virus (whole virus/TBEV/FSME) vaccine by ELISA

960-800-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Malaria Proteins (CSP/MSP-1/MSP-2/DBL5/VAR2CSA) by ELISA

970-400-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to H. Influenzae protein D (Non-typeable, NT-PHiD) vaccine by ELISA

980-200-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Tick Borne Encephalitis Virus (whole virus/TBEV/FSME) vaccine by ELISA

990-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Hepatitis B vaccine proteins (HBsAg/PreS/Pre-S1/Pre-S2) by ELISA

4200-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to B. pertussis vaccine (Toxin/Toxoid/LPS/FHA/PRN/Fim2/3) by ELISA

960-100-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Human Anti-Herpes Simplex Virus 1/2 (HSV-1/HSV-2) by ELISA

3300-380-CUX Custom Ask for price

Human Anti-S. Pneumococcal CWPS/22F IgG ELISA kit (for the adsorption of non-sp. Anti-CWPS and 22F antibodies), 96 tests, quantitative

560-410-C22 1 Kit
EUR 712.00

Human Anti-S. Pneumococcal CWPS/22F IgM ELISA kit (for the adsorption of non-sp. Anti-CWPS and 22F antibodies), 96 tests, quantitative

560-415-C22 1 Kit
EUR 712.00

Rabbit Anti-S. Pneumococcal CWPS/22F IgG ELISA kit (for the adsorption of non-sp. Anti-CWPS and 22F antibodies), 96 tests, quantitative

560-420-C22 1 Kit
EUR 712.00

Rabbit Anti-S. Pneumococcal CWPS/22F IgM ELISA kit (for the adsorption of non-sp. Anti-CWPS and 22F antibodies), 96 tests, quantitative

560-425-C22 1 Kit
EUR 712.00

Mouse Anti-S. Pneumococcal CWPS/22F IgG ELISA kit (for the adsorption of non-sp. Anti-CWPS and 22F antibodies), 96 tests, quantitative

560-430-C22 1 Kit
EUR 712.00

Mouse Anti-S. Pneumococcal CWPS/22F IgM ELISA kit (for the adsorption of non-sp. Anti-CWPS and 22F antibodies), 96 tests, quantitative

560-435-C22 1 Kit
EUR 712.00

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Epstein Barr Virus (EBV/HHV-4) proteins (EBNA-1/EA/VCA/ED) by ELISA

510-200-CUX Custom Ask for price

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Human Papilloma Viruses (HPV6/11/16/18/33/45/52/52; Gardasil 5/9) vaccines by ELISA

550-000-CUX Custom Ask for price

Identification of a metabolism-related gene expression prognostic model in endometrial carcinoma patients

Background: Metabolic abnormalities have recently been widely studied in various cancer types. This study aims to explore the expression profiles of metabolism-related genes (MRGs) in endometrial cancer (EC).
Methods: We analyzed the expression of MRGs using The Cancer Genome Atlas (TCGA) data to screen differentially expressed MRGs (DE-MRGs) significantly correlated with EC patient prognosis. Functional pathway enrichment analysis of the DE-MRGs was performed. LASSO and Cox regression analyses were performed to select MRGs closely related to EC patient outcomes. A prognostic signature was developed, and the efficacy was validated in part of and the entire TCGA EC cohort. Moreover, we developed a comprehensive nomogram including the risk model and clinical features to predict EC patients’ survival probability.
Results: Forty-seven DE-MRGs were significantly correlated with EC patient prognosis. Functional enrichment analysis showed that these MRGs were highly enriched in amino acid, glycolysis, and glycerophospholipid metabolism.
Nine MRGs were found to be closely related to EC patient outcomes: CYP4F3, CEL, GPAT3, LYPLA2, HNMT, PHGDH, CKM, UCK2 and ACACB. Based on these nine DE-MRGs, we developed a prognostic signature, and its efficacy in part of and the entire TCGA EC cohort was validated. The nine-MRG signature was independent of other clinical features, and could effectively distinguish high- and low-risk EC patients and predict patient OS. The nomogram showed excellent consistency between the predictions and actual survival observations.
Conclusions: The MRG prognostic model and the comprehensive nomogram could guide precise outcome prediction and rational therapy selection in clinical practice.

Molecular Genetic Analysis of α-Thalassemia in Hamadan Province, West Iran

  • Identifying couples who are carriers of thalassemia-causing mutations, followed by prenatal diagnosis (PND), is undoubtedly an effective way to prevent the birth of children with the disease. Our aim in this study was to report for the first time the spectrum of α-globin gene mutations in the population living in Hamadan Province, West Iran.
  • Multiplex gap-polymerase chain reaction (gap-PCR), amplification refractory mutation system (ARMS)-PCR, and direct DNA sequencing of HBA1 and HBA2 genes were used to identify the α-thalassemia (α-thal)-causing mutations in a cohort of 389 individuals including 328 α-thal carriers and 61 normal subjects. A total of 17 different mutations and 25 different genotypes were detected. The 3.7 (rightward) deletion (NG_000006.1: g.34164_37967del3804) was the most frequent mutation, accounting for more than half of all mutations (61.04%).
  • This study revealed that there is a variety of α-thal mutations and α-thal genotypes in Hamadan Province, West Iran. This observation is probably due to the complexity of the Hamadan Province population that is composed of Persians (Fars), Turks, Kurds, and Lurs/Laks. In conclusion, our results demonstrated the spectrum of mutations in α-globin genes in Iran and increased our understanding of their distribution in this country.

Mouse antibody for Rhinovirus VP3

4967 100 ug
EUR 321.88
Description: This is purified Mouse monoclonal antibody against Rhinovirus VP3 for WB, ELISA.

Human Recombinant PTP1B

6301-100
EUR 332.00

Human Recombinant PIN1

6304-100
EUR 425.00

Human Recombinant Thioredoxin

6305-100
EUR 332.00

Human Recombinant UCHL1

6306-100
EUR 425.00

Human Recombinant PPIL1

6317-100
EUR 370.00

Human Recombinant PPIL2

6325-50
EUR 490.00

Human Recombinant PPIL3

6326-100
EUR 457.00

Human Recombinant PPIL4

6327-50
EUR 490.00

Human Recombinant TXNRD1

6330-100
EUR 457.00

Human Recombinant ALDH2

6332-100
EUR 425.00

Human Recombinant ALDH3A1

6333-50
EUR 490.00

Human Recombinant AKR7A3

6334-50
EUR 490.00

Human Recombinant AKR7A2

6335-100
EUR 492.00

Human Recombinant AKR1C1

6336-100
EUR 425.00

Human Recombinant AKR1C3

6337-100
EUR 474.00

Human Recombinant AKR1C3

6337-1000
EUR 2437.00

Human Recombinant AKR1C4

6338-100
EUR 457.00

AKR1B10, human recombinant

6339-100
EUR 457.00

AKR1B10, human recombinant

6339-1000
EUR 1599.00

Human Recombinant FKBP1B

6341-100
EUR 457.00

Human Recombinant FKBP3

6342-100
EUR 425.00

Human Recombinant FKBP4

6343-100
EUR 381.00

Human Recombinant FKBP6

6344-50
EUR 457.00

Human Recombinant FKBPL

6345-10
EUR 457.00

Human Recombinant GSTA1

6346-100
EUR 425.00

Human Recombinant GSTP1

6347-100
EUR 506.00

Human Recombinant GSR

6352-50
EUR 403.00

Human Recombinant FKBP2

6353-50
EUR 457.00

Human Recombinant FKBP14

6354-100
EUR 425.00

Human Recombinant MDH1

6355-100
EUR 479.00

Human Recombinant MDH2

6356-50
EUR 479.00

Human Recombinant UCHL3

6358-100
EUR 403.00

Human Recombinant UCHL5

6359-100
EUR 457.00

Human Recombinant UGDH

6368-50
EUR 468.00

Human Recombinant PPM1G

6369-50
EUR 436.00

Human Recombinant PPP1CA

6370-10
EUR 403.00

Human Recombinant DUSP3

6371-100
EUR 457.00

Human Recombinant PKM2

6372-100
EUR 381.00

Human Recombinant PKLR

6373-50
EUR 436.00

Human Recombinant LDHA

6374-100
EUR 381.00

Human Recombinant LDHB

6375-100
EUR 381.00

Human Recombinant IDH1

6379-100
EUR 457.00

Human Recombinant DHFR

6382-100
EUR 332.00

Human Recombinant Fumarase

6384-100
EUR 370.00

Human Recombinant AK1

6385-100
EUR 457.00

Human Recombinant AK2

6386-100
EUR 457.00

Human Recombinant PIN4

6387-100
EUR 490.00

Human Recombinant SORD

6388-100
EUR 425.00

Human Recombinant NDRG1

6391-100
EUR 370.00

Human Recombinant BLMH

6392-100
EUR 457.00

Human Recombinant ADA

6393-50
EUR 436.00

Human recombinant UBE2D3

6430-3
EUR 365.00

Human recombinant UBE2L3

6431-3
EUR 365.00

PTEN, human recombinant

4838-5
EUR 588.00

Ubiquitin, human recombinant

4841-100
EUR 289.00

Ubiquitin, human recombinant

4841-1000
EUR 1529.00

CRP, human recombinant

4863-10
EUR 256.00

CRP, human recombinant

4863-1000
EUR 5270.00

CRP, human recombinant

4863-50
EUR 588.00

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