The Drosophila CG1674 gene encodes a Synaptopodin-like 2 related protein that localizes to the Z-disc and is required for normal flight muscle development and function
Background: To identify novel myofibrillar components of the Drosophila flight muscles, we carried out a proteomic analysis of chemically demembranated flight muscle myofibrils, and characterized the knockdown phenotype of a novel gene identified in the screen, CG1674.
Results: The CG1674 protein has some similarity to vertebrate synaptopodin 2-like, and when expressed as a FLAG-tagged fusion protein, it was localized during development to the Z-disc and cytoplasm. Knockdown of CG1674 expression affected the function of multiple muscle types, and defective flight in adults was accompanied by large actin-rich structures in the flight muscles that resembled overgrown Z-discs. Localization of CG1674 to the Z-disc depended predominantly upon presence of the Z-disc component alpha-actinin, but also depended upon other Z-disc components, including Mask, Zasp52, and Sals. We also observed re-localization of FLAG-CG1674 to the nucleus in Alpha-actinin and sals knockdown animals.
Conclusions: These studies identify and characterize a previously unreported myofibrillar component of Drosophila muscle, that is necessary for proper myofibril assembly during development. This article is protected by copyright. All rights reserved.

![]() Genome polyprotein Antibody |
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20-abx300967 | Abbexa |
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![]() Genome Polyprotein Antibody (Biotin) |
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20-abx105887 | Abbexa |
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![]() Genome polyprotein Antibody (Biotin) |
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20-abx106264 | Abbexa |
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![]() Genome polyprotein Antibody (FITC) |
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20-abx107678 | Abbexa |
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![]() Genome polyprotein Antibody (HRP) |
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20-abx109095 | Abbexa |
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![]() Genome polyprotein Antibody (HRP) |
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20-abx300968 | Abbexa |
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![]() Genome polyprotein Antibody (FITC) |
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20-abx300969 | Abbexa |
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![]() Genome polyprotein Antibody (Biotin) |
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20-abx300970 | Abbexa |
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![]() Genome Polyprotein Polyclonal Antibody |
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A68253 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein Polyclonal Antibody |
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A68254 | EpiGentek | 100 µg | EUR 570.55 |
Description: reagents widely cited |
![]() Genome Polyprotein Polyclonal Antibody |
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A56743 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein Polyclonal Antibody |
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A56130 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein (HCV-Core) Antibody |
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33487-05111 | AssayPro | 150 ug | EUR 261.00 |
![]() Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA714772LB01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is HRP conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA714772LC01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is FITC conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA714772LD01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Biotin conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA362073LB01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is HRP conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA362073LC01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is FITC conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA362073LD01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Biotin conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA333180LB01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is HRP conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA333180LC01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is FITC conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA333180LD01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Biotin conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA18549B0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is HRP conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA18549C0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is FITC conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA18549D0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Biotin conjugated. Tested in the following application: ELISA |
![]() Enterovirus 71 Genome polyprotein Antibody |
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20-abx109758 | Abbexa |
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![]() Hepatitis C Genome polyprotein |
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1-CSB-RP184674Ba | Cusabio |
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Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli |
![]() Enterovirus 71 Genome polyprotein Antibody (Biotin) |
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20-abx105382 | Abbexa |
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![]() Enterovirus 71 Genome polyprotein Antibody (FITC) |
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20-abx106801 | Abbexa |
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![]() Enterovirus 71 Genome polyprotein Antibody (HRP) |
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20-abx108220 | Abbexa |
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![]() Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A68250 | EpiGentek | 100 µg | EUR 570.55 |
Description: reagents widely cited |
![]() Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A68251 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A68252 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
![]() Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A68255 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A68256 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
![]() Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A68257 | EpiGentek | 100 µg | EUR 570.55 |
Description: kits suitable for this type of research |
![]() Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A56744 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
![]() Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A56745 | EpiGentek | 100 µg | EUR 570.55 |
Description: kits suitable for this type of research |
![]() Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A56746 | EpiGentek | 100 µg | EUR 570.55 |
Description: fast delivery possible |
![]() Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A56131 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
![]() Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A56132 | EpiGentek | 100 µg | EUR 570.55 |
Description: kits suitable for this type of research |
![]() Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A56133 | EpiGentek | 100 µg | EUR 570.55 |
Description: fast delivery possible |
![]() Japanese encephalitis virus Genome polyprotein |
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1-CSB-EP189574Ba | Cusabio |
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Description: Recombinant Japanese encephalitis virus Genome polyprotein,partial expressed in E.coli |
![]() Yellow fever virus Genome polyprotein |
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1-CSB-EP365905YAC1 | Cusabio |
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Description: Recombinant Yellow fever virus Genome polyprotein,partial expressed in E.coli |
![]() Human rhinovirus 1A Genome polyprotein |
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1-CSB-YP326367HQA | Cusabio |
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Description: Recombinant Human rhinovirus 1A Genome polyprotein,partial expressed in Yeast |
![]() Genome Polyprotein (HCV-Core) Antibody (Biotin Conjugate) |
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33487-05121 | AssayPro | 150 ug | EUR 369.00 |
![]() Rhinovirus A serotype 89 Genome polyprotein Antibody |
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20-abx109372 | Abbexa |
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![]() Genome Polyprotein (HCV-Core) AssayLite Antibody (FITC Conjugate) |
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33487-05141 | AssayPro | 150 ug | EUR 428.00 |
![]() Genome Polyprotein (HCV-Core) AssayLite Antibody (RPE Conjugate) |
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33487-05151 | AssayPro | 150 ug | EUR 428.00 |
![]() Genome Polyprotein (HCV-Core) AssayLite Antibody (APC Conjugate) |
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33487-05161 | AssayPro | 150 ug | EUR 428.00 |
![]() Genome Polyprotein (HCV-Core) AssayLite Antibody (PerCP Conjugate) |
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33487-05171 | AssayPro | 150 ug | EUR 471.00 |
![]() Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC) |
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20-abx107303 | Abbexa |
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![]() Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP) |
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20-abx108723 | Abbexa |
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![]() Hepatitis C virus genotype 1a Genome polyprotein |
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1-CSB-MP333180HFD | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in Mammalian cell |
![]() Hepatitis C virus genotype 1a Genome polyprotein |
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1-CSB-EP333180HFD | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in E.coli |
![]() Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-EP362073HQD | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli |
![]() Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-EP362073HQDb0 | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli |
![]() Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-YP362073HQD | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in Yeast |
![]() Hepatitis C virus genotype 1b Genome polyprotein |
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1-CSB-YP530838HVQ(A3) | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast |
![]() Hepatitis C virus genotype 1b Genome polyprotein |
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1-CSB-YP530838HVQ(A4) | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast |
![]() Recombinant Human Genome polyprotein, His, Yeast-100ug |
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QP7370-ye-100ug | EnQuireBio | 100ug | EUR 480.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-10ug |
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QP7370-ye-10ug | EnQuireBio | 10ug | EUR 236.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-1mg |
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QP7370-ye-1mg | EnQuireBio | 1mg | EUR 1885.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-200ug |
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QP7370-ye-200ug | EnQuireBio | 200ug | EUR 744.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-500ug |
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QP7370-ye-500ug | EnQuireBio | 500ug | EUR 1206.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-50ug |
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QP7370-ye-50ug | EnQuireBio | 50ug | EUR 299.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-100ug |
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QP7370-ec-100ug | EnQuireBio | 100ug | EUR 408.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-10ug |
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QP7370-ec-10ug | EnQuireBio | 10ug | EUR 200.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-1mg |
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QP7370-ec-1mg | EnQuireBio | 1mg | EUR 1632.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug |
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QP7370-ec-200ug | EnQuireBio | 200ug | EUR 634.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug |
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QP7370-ec-500ug | EnQuireBio | 500ug | EUR 1060.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-50ug |
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QP7370-ec-50ug | EnQuireBio | 50ug | EUR 263.00 |
![]() Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4793.00 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3048.00 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 903.00 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 2840.00 |
Description: YFV Genome polyprotein, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2044.00 |
Description: YFV Genome polyprotein, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1411.00 |
Description: YFV Genome polyprotein, recombinant protein. |
![]() Recombinant JEV Genome polyprotein (aa 2528-3432) Protein |
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VAng-Wyb3447-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 8272.00 |
Description: Japanese encephalitis virus (strain Jaoars982) Genome polyprotein, recombinant protein. |
![]() Recombinant YFV Genome polyprotein (NS4A) Protein (aa 1-3412) |
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VAng-Cr6545-inquire | Creative Biolabs | inquire | Ask for price |
Description: YFV (isolate Uganda/A7094A4/1948) Genome polyprotein (NS4A), recombinant protein. |
![]() Gag Polyprotein (gag) Antibody |
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20-abx318946 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody |
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abx331332-100ul | Abbexa | 100 ul | EUR 425.00 |
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![]() Gag Polyprotein (gag) Antibody |
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20-abx317799 | Abbexa |
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![]() Structural Polyprotein (VP2) Antibody |
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abx224337-100ug | Abbexa | 100 ug | EUR 411.00 |
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![]() Gag Polyprotein (GAG) Antibody (Biotin) |
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20-abx106336 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody (FITC) |
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20-abx107749 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody (HRP) |
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20-abx318947 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody (FITC) |
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20-abx318948 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody (Biotin) |
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20-abx318949 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody (HRP) |
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20-abx317800 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody (FITC) |
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20-abx317801 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody (Biotin) |
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20-abx317802 | Abbexa |
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![]() Non-Structural Polyprotein Porf1 (ORF1) Antibody |
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20-abx300971 | Abbexa |
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![]() Turnip mosaic virus Polyprotein |
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1-CSB-EP2708TJM | Cusabio |
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Description: Recombinant Turnip mosaic virus Polyprotein,partial expressed in E.coli |
![]() Sindbis virus Structural polyprotein |
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1-CSB-CF361018SHZ | Cusabio |
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Description: Recombinant Sindbis virus Structural polyprotein,partial expressed in in vitro E.coli expression system |
![]() Sindbis virus Structural polyprotein |
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1-CSB-CF361018SHZb2 | Cusabio |
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Description: Recombinant Sindbis virus Structural polyprotein,partial expressed in in vitro E.coli expression system |
![]() Recombinant CHIKV Structural Polyprotein |
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VAng-Lsx0030-inquire | Creative Biolabs | inquire | Ask for price |
Description: CHIKV Structural Polyprotein, recombinant protein from E. coli. |
![]() Mitochondrial Genome Maintenance Exonuclease 1 (MGME1) Antibody |
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abx235168-100ug | Abbexa | 100 ug | EUR 509.00 |
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![]() Mitochondrial Genome Maintenance Exonuclease 1 (MGME1) Antibody |
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20-abx302859 | Abbexa |
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![]() HIV-1 Gag-Pol polyprotein Antibody (Biotin) |
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20-abx106322 | Abbexa |
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![]() HIV-1 Gag-Pol polyprotein Antibody (FITC) |
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20-abx107735 | Abbexa |
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![]() Moloney murine leukemia virus Gag polyprotein Antibody |
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20-abx110606 | Abbexa |
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![]() HIV-1 Gag-Pol polyprotein Antibody (HRP) |
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20-abx109153 | Abbexa |
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![]() Pre-Glycoprotein Polyprotein GP Complex (GPC) Antibody |
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20-abx319921 | Abbexa |
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![]() Genome edited iPSCs (KO) PARK2-/- |
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ASE-9400 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Genome edited iPSCs (KO) PARK7-/- |
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ASE-9401 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Genome edited iPSCs (KO) PINK1-/- |
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ASE-9402 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Genome edited iPSCs (KO) LRRK2-/- |
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ASE-9403 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Genome edited iPSCs (KO) BDNF-/- |
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ASE-9404 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Genome edited iPSCs (KO) APOE-/- |
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ASE-9405 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Genome edited iPSCs (KO) DISC1-/- |
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ASE-9406 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Genome edited iPSCs (KO) SOD1-/- |
|||
ASE-9407 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Genome edited iPSCs (KO) CNTNAP2-/- |
|||
ASE-9408 | Applied StemCell | 1 vial (1 x 10^6) | EUR 3087.50 |
Description: 12 month |
![]() Recombinant MAYV Structural polyprotein Protein |
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VAng-Wyb3702-inquire | Creative Biolabs | inquire | Ask for price |
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein. |
![]() Recombinant MLV Radiation Pol Polyprotein |
|||
VAng-Lsx0414-inquire | Creative Biolabs | inquire | Ask for price |
Description: MLV Radiation Pol Polyprotein, recombinant protein from E. coli. |
![]() Recombinant CHIKV Non-structural Polyprotein |
|||
VAng-Lsx0031-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4168.00 |
Description: CHIKV Non-structural Polyprotein, recombinant protein from E. coli. |
![]() Recombinant CHIKV Non-structural Polyprotein |
|||
VAng-Lsx0031-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2788.00 |
Description: CHIKV Non-structural Polyprotein, recombinant protein from E. coli. |
![]() RecQ-Mediated Genome Instability Protein 2 (RMI2) Antibody |
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20-abx005864 | Abbexa |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody |
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20-abx003807 | Abbexa |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody |
|||
20-abx115306 | Abbexa |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody |
|||
abx145095-100ug | Abbexa | 100 ug | EUR 391.00 |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody |
|||
abx029125-400ul | Abbexa | 400 ul | EUR 523.00 |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody |
|||
abx029125-80l | Abbexa | 80 µl | EUR 286.00 |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody |
|||
20-abx318666 | Abbexa |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody |
|||
abx237321-100ug | Abbexa | 100 ug | EUR 551.00 |
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![]() Mitochondrial Genome Maintenance Exonuclease 1 (MGME1) Antibody (HRP) |
|||
20-abx311506 | Abbexa |
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![]() Mitochondrial Genome Maintenance Exonuclease 1 (MGME1) Antibody (FITC) |
|||
20-abx311507 | Abbexa |
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![]() Mitochondrial Genome Maintenance Exonuclease 1 (MGME1) Antibody (Biotin) |
|||
20-abx311508 | Abbexa |
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![]() HIV-1 Gag-Pol Polyprotein (gag-pol) Antibody |
|||
20-abx110593 | Abbexa |
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![]() Moloney murine leukemia virus Gag polyprotein Antibody (HRP) |
|||
20-abx109167 | Abbexa |
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![]() Pre-Glycoprotein Polyprotein GP Complex (GPC) Antibody (HRP) |
|||
20-abx319922 | Abbexa |
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![]() Pre-Glycoprotein Polyprotein GP Complex (GPC) Antibody (FITC) |
|||
20-abx319923 | Abbexa |
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![]() Pre-Glycoprotein Polyprotein GP Complex (GPC) Antibody (Biotin) |
|||
20-abx319924 | Abbexa |
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![]() HIV-1 gag Polyprotein (121-140) |
|||
H-4776.0500 | Bachem | 0.5mg | EUR 708.00 |
Description: Sum Formula: C86H138N26O34; CAS# [1815618-20-2] |
![]() HIV-1 gag Polyprotein (121-140) |
|||
H-4776.1000 | Bachem | 1.0mg | EUR 1240.00 |
Description: Sum Formula: C86H138N26O34; CAS# [1815618-20-2] |
![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody (HRP) |
|||
20-abx311381 | Abbexa |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody (FITC) |
|||
20-abx311382 | Abbexa |
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![]() RecQ-Mediated Genome Instability Protein 1 (RMI1) Antibody (Biotin) |
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20-abx311383 | Abbexa |
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![]() Moloney murine leukemia virus Gag polyprotein (gag) |
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1-CSB-EP356017MHK | Cusabio |
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Description: Recombinant Moloney murine leukemia virus Gag polyprotein(gag) ,partial expressed in E.coli |
![]() Moloney murine leukemia virus Gag polyprotein (gag) |
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1-CSB-EP356017MHKe0 | Cusabio |
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Description: Recombinant Moloney murine leukemia virus Gag polyprotein(gag),partial expressed in E.coli |
![]() Avian infectious bursal disease virus Structural polyprotein |
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1-CSB-RP182094V | Cusabio |
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Description: Recombinant Avian infectious bursal disease virus Structural polyprotein,partial expressed in E.coli |
![]() Lassa virus Pre-glycoprotein polyprotein GP complex (GPC) |
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1-CSB-EP362480LNP2 | Cusabio |
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Description: Recombinant Lassa virus Pre-glycoprotein polyprotein GP complex(GPC),partial expressed in E.coli |
![]() Recombinant Hepatitis C Virus polyprotein, His, E.coli-100ug |
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QP8939-ec-100ug | EnQuireBio | 100ug | EUR 707.00 |
![]() Recombinant Hepatitis C Virus polyprotein, His, E.coli-10ug |
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QP8939-ec-10ug | EnQuireBio | 10ug | EUR 326.00 |
![]() Recombinant Hepatitis C Virus polyprotein, His, E.coli-1mg |
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QP8939-ec-1mg | EnQuireBio | 1mg | EUR 2303.00 |
![]() Recombinant Hepatitis C Virus polyprotein, His, E.coli-200ug |
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QP8939-ec-200ug | EnQuireBio | 200ug | EUR 1115.00 |
![]() Recombinant Hepatitis C Virus polyprotein, His, E.coli-500ug |
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QP8939-ec-500ug | EnQuireBio | 500ug | EUR 1514.00 |
![]() Recombinant Hepatitis C Virus polyprotein, His, E.coli-50ug |
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QP8939-ec-50ug | EnQuireBio | 50ug | EUR 435.00 |
![]() Recombinant JEV Polyprotein NS5 (aa 2780-3428) Protein |
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VAng-Wyb3462-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3294.00 |
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein. |
![]() Recombinant JEV Polyprotein NS5 (aa 2780-3428) Protein |
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VAng-Wyb3462-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2113.00 |
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein. |
Accelerated cortical thinning and volume reduction over time in young people at high genetic risk for bipolar disorder
- Background: Bipolar disorder (BD) is a familial psychiatric disorder associated with frontotemporal and subcortical brain abnormalities. It is unclear whether such abnormalities are present in relatives without BD, and little is known about structural brain trajectories in those at risk.
- Method: Neuroimaging was conducted at baseline and at 2-year follow-up interval in 90 high-risk individuals with a first-degree BD relative (HR), and 56 participants with no family history of mental illness who could have non-BD diagnoses. All 146 subjects were aged 12-30 years at baseline. We examined longitudinal change in gray and white matter volume, cortical thickness, and surface area in the frontotemporal cortex and subcortical regions.
- Results: Compared to controls, HR participants showed accelerated cortical thinning and volume reduction in right lateralised frontal regions, including the inferior frontal gyrus, lateral orbitofrontal cortex, frontal pole and rostral middle frontal gyrus. Independent of time, the HR group had greater cortical thickness in the left caudal anterior cingulate cortex, larger volume in the right medial orbitofrontal cortex and greater area of right accumbens, compared to controls. This pattern was evident even in those without the new onset of psychopathology during the inter-scan interval.
- Conclusions: This study suggests that differences previously observed in BD are developing prior to the onset of the disorder. The pattern of pathological acceleration of cortical thinning is likely consistent with a disturbance of molecular mechanisms responsible for normal cortical thinning. We also demonstrate that neuroanatomical differences in HR individuals may be progressive in some regions and stable in others.
Challenges in gene-oriented approaches for pangenome content discovery
Given a group of genomes, represented as the sets of genes that belong to them, the discovery of the pangenomic content is based on the search of genetic homology among the genes for clustering them into families. Thus, pangenomic analyses investigate the membership of the families to the given genomes.
This approach is referred to as the gene-oriented approach in contrast to other definitions of the problem that takes into account different genomic features. In the past years, several tools have been developed to discover and analyse pangenomic contents. Because of the hardness of the problem, each tool applies a different strategy for discovering the pangenomic content. This results in a differentiation of the performance of each tool that depends on the composition of the input genomes. This review reports the main analysis instruments provided by the current state of the art tools for the discovery of pangenomic contents.
Moreover, unlike previous works, the presented study compares pangenomic tools from a methodological perspective, analysing the causes that lead a given methodology to outperform other tools. The analysis is performed by taking into account different bacterial populations, which are synthetically generated by changing evolutionary parameters.
The benchmarks used to compare the pangenomic tools, in addition to the computational pipeline developed for this purpose, are available at https://github.com/InfOmics/pangenes-review. Contact: V. Bonnici, R. Giugno Supplementary information: Supplementary data are available at Briefings in Bioinformatics online.
![]() Genome Polyprotein Antibody (Biotin) |
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20-abx105887 | Abbexa |
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![]() Genome polyprotein Antibody (Biotin) |
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20-abx106264 | Abbexa |
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![]() Genome polyprotein Antibody (FITC) |
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20-abx107678 | Abbexa |
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![]() Genome polyprotein Antibody (HRP) |
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20-abx109095 | Abbexa |
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![]() Genome polyprotein Antibody (HRP) |
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20-abx300968 | Abbexa |
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![]() Genome polyprotein Antibody (FITC) |
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20-abx300969 | Abbexa |
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![]() Genome polyprotein Antibody (Biotin) |
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20-abx300970 | Abbexa |
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![]() Genome Polyprotein Polyclonal Antibody |
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A68253 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein Polyclonal Antibody |
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A68254 | EpiGentek | 100 µg | EUR 570.55 |
Description: reagents widely cited |
![]() Genome Polyprotein Polyclonal Antibody |
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A56743 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein Polyclonal Antibody |
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A56130 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein (HCV-Core) Antibody |
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33487-05111 | AssayPro | 150 ug | EUR 261.00 |
![]() Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA714772LB01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is HRP conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA714772LC01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is FITC conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA714772LD01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Biotin conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA362073LB01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is HRP conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA362073LC01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is FITC conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA362073LD01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Biotin conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA333180LB01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is HRP conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA333180LC01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is FITC conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA333180LD01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Biotin conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA18549B0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is HRP conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA18549C0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is FITC conjugated. Tested in the following application: ELISA |
![]() Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA18549D0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Biotin conjugated. Tested in the following application: ELISA |
![]() Enterovirus 71 Genome polyprotein Antibody |
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20-abx109758 | Abbexa |
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![]() Hepatitis C Genome polyprotein |
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1-CSB-RP184674Ba | Cusabio |
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Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli |
![]() Enterovirus 71 Genome polyprotein Antibody (Biotin) |
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20-abx105382 | Abbexa |
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![]() Enterovirus 71 Genome polyprotein Antibody (FITC) |
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20-abx106801 | Abbexa |
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![]() Enterovirus 71 Genome polyprotein Antibody (HRP) |
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20-abx108220 | Abbexa |
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![]() Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A68250 | EpiGentek | 100 µg | EUR 570.55 |
Description: reagents widely cited |
![]() Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A68251 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A68252 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
![]() Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A68255 | EpiGentek | 100 µg | EUR 570.55 |
Description: Ask the seller for details |
![]() Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A68256 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
![]() Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A68257 | EpiGentek | 100 µg | EUR 570.55 |
Description: kits suitable for this type of research |
![]() Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A56744 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
![]() Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A56745 | EpiGentek | 100 µg | EUR 570.55 |
Description: kits suitable for this type of research |
![]() Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A56746 | EpiGentek | 100 µg | EUR 570.55 |
Description: fast delivery possible |
![]() Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A56131 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
![]() Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A56132 | EpiGentek | 100 µg | EUR 570.55 |
Description: kits suitable for this type of research |
![]() Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A56133 | EpiGentek | 100 µg | EUR 570.55 |
Description: fast delivery possible |
![]() Japanese encephalitis virus Genome polyprotein |
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1-CSB-EP189574Ba | Cusabio |
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Description: Recombinant Japanese encephalitis virus Genome polyprotein,partial expressed in E.coli |
![]() Yellow fever virus Genome polyprotein |
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1-CSB-EP365905YAC1 | Cusabio |
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Description: Recombinant Yellow fever virus Genome polyprotein,partial expressed in E.coli |
![]() Human rhinovirus 1A Genome polyprotein |
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1-CSB-YP326367HQA | Cusabio |
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Description: Recombinant Human rhinovirus 1A Genome polyprotein,partial expressed in Yeast |
![]() Genome Polyprotein (HCV-Core) Antibody (Biotin Conjugate) |
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33487-05121 | AssayPro | 150 ug | EUR 369.00 |
![]() Rhinovirus A serotype 89 Genome polyprotein Antibody |
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20-abx109372 | Abbexa |
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![]() Genome Polyprotein (HCV-Core) AssayLite Antibody (FITC Conjugate) |
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33487-05141 | AssayPro | 150 ug | EUR 428.00 |
![]() Genome Polyprotein (HCV-Core) AssayLite Antibody (RPE Conjugate) |
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33487-05151 | AssayPro | 150 ug | EUR 428.00 |
![]() Genome Polyprotein (HCV-Core) AssayLite Antibody (APC Conjugate) |
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33487-05161 | AssayPro | 150 ug | EUR 428.00 |
![]() Genome Polyprotein (HCV-Core) AssayLite Antibody (PerCP Conjugate) |
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33487-05171 | AssayPro | 150 ug | EUR 471.00 |
![]() Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC) |
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20-abx107303 | Abbexa |
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![]() Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP) |
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20-abx108723 | Abbexa |
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![]() Hepatitis C virus genotype 1a Genome polyprotein |
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1-CSB-MP333180HFD | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in Mammalian cell |
![]() Hepatitis C virus genotype 1a Genome polyprotein |
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1-CSB-EP333180HFD | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in E.coli |
![]() Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-EP362073HQD | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli |
![]() Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-EP362073HQDb0 | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli |
![]() Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-YP362073HQD | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in Yeast |
![]() Hepatitis C virus genotype 1b Genome polyprotein |
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1-CSB-YP530838HVQ(A3) | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast |
![]() Hepatitis C virus genotype 1b Genome polyprotein |
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1-CSB-YP530838HVQ(A4) | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast |
![]() Recombinant Human Genome polyprotein, His, Yeast-100ug |
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QP7370-ye-100ug | EnQuireBio | 100ug | EUR 480.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-10ug |
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QP7370-ye-10ug | EnQuireBio | 10ug | EUR 236.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-1mg |
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QP7370-ye-1mg | EnQuireBio | 1mg | EUR 1885.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-200ug |
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QP7370-ye-200ug | EnQuireBio | 200ug | EUR 744.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-500ug |
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QP7370-ye-500ug | EnQuireBio | 500ug | EUR 1206.00 |
![]() Recombinant Human Genome polyprotein, His, Yeast-50ug |
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QP7370-ye-50ug | EnQuireBio | 50ug | EUR 299.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-100ug |
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QP7370-ec-100ug | EnQuireBio | 100ug | EUR 408.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-10ug |
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QP7370-ec-10ug | EnQuireBio | 10ug | EUR 200.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-1mg |
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QP7370-ec-1mg | EnQuireBio | 1mg | EUR 1632.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug |
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QP7370-ec-200ug | EnQuireBio | 200ug | EUR 634.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug |
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QP7370-ec-500ug | EnQuireBio | 500ug | EUR 1060.00 |
![]() Recombinant Human Genome polyprotein, His-SUMO, E.coli-50ug |
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QP7370-ec-50ug | EnQuireBio | 50ug | EUR 263.00 |
![]() Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 4793.00 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3048.00 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 903.00 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 2840.00 |
Description: YFV Genome polyprotein, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2044.00 |
Description: YFV Genome polyprotein, recombinant protein. |
![]() Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1411.00 |
Description: YFV Genome polyprotein, recombinant protein. |
![]() Recombinant JEV Genome polyprotein (aa 2528-3432) Protein |
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VAng-Wyb3447-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 8272.00 |
Description: Japanese encephalitis virus (strain Jaoars982) Genome polyprotein, recombinant protein. |
![]() Recombinant YFV Genome polyprotein (NS4A) Protein (aa 1-3412) |
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VAng-Cr6545-inquire | Creative Biolabs | inquire | Ask for price |
Description: YFV (isolate Uganda/A7094A4/1948) Genome polyprotein (NS4A), recombinant protein. |
![]() Gag Polyprotein (gag) Antibody |
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20-abx318946 | Abbexa |
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![]() Gag Polyprotein (GAG) Antibody |
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abx331332-100ul | Abbexa | 100 ul | EUR 425.00 |
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![]() Gag Polyprotein (gag) Antibody |
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20-abx317799 | Abbexa |
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