December 3, 2022
musagenomics
Antibodies / Biology Cells / Gels / PCR / Reagents / Western Blot

Spectrum of PAH gene mutations and genotype-phenotype

Alecby Alec

Spectrum of PAH gene mutations and genotype-phenotype correlation in patients with phenylalanine hydroxylase deficiency from Shanxi province

Background: Phenylalanine hydroxylase deficiency (PAHD) is an autosomal recessive inborn error that affects phenylalanine (Phe) metabolism. It has a complex phenotype with many variants and genotypes among different populations. Shanxi province is a high-prevalence area of PAHD in China.
Methods: In this study, eighty-nine PAHD patients were subjected to genetic testing using Sanger sequencing, followed by multiplex ligation-dependent probe amplification analysis (MLPA). Allelic and genotypic phenotype values (APV and GPV, respectively) were used for genotype-based phenotypic prediction.
Results: Fifty-one types of variants, including three novel forms, were identified. The predominant variant was p.R243Q (22.09%), followed by p.R53H (10.47%), p.EX6-96A > G (9.30%), p.V399V (5.23%) and p.R413P (3.49%). Notably, mild hyperphenylalaninemia (MHP) has a high prevalence in this region (up to 45.76%), and the variant p.R53H was solely observed in patients of MHP. According to the genotype-phenotype prediction, the APV/GPV system was well correlated with the metabolic phenotype of most PAHD patients.
Conclusion: We have systematically constructed the mutational and phenotypic spectrum of PAH in Shanxi province. Hence, this study will help to further understand the genotype-phenotype associations in PAHD patients, and it may offer more reliable genetic counseling and management.
musagenomics
musagenomics

Genome polyprotein Antibody
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  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Unconjugated. Tested in the following application: ELISA

Genome Polyprotein Antibody
20-abx109417
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A68253 100 µg
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Description: Ask the seller for details

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A68254 100 µg
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Description: reagents widely cited

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Genome polyprotein Antibody (FITC)
20-abx300969
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Genome polyprotein Antibody (Biotin)
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  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is HRP conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, FITC conjugated
1-CSB-PA333180LC01HFD
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  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is FITC conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, Biotin conjugated
1-CSB-PA333180LD01HFD
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Biotin conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, HRP conjugated
1-CSB-PA714772LB01HYH
  • EUR 317.00
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  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is HRP conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, FITC conjugated
1-CSB-PA714772LC01HYH
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is FITC conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, Biotin conjugated
1-CSB-PA714772LD01HYH
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Biotin conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, HRP conjugated
1-CSB-PA18549B0Rb
  • EUR 317.00
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  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is HRP conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, FITC conjugated
1-CSB-PA18549C0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is FITC conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, Biotin conjugated
1-CSB-PA18549D0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Biotin conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, HRP conjugated
1-CSB-PA362073LB01HQD
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is HRP conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, FITC conjugated
1-CSB-PA362073LC01HQD
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is FITC conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, Biotin conjugated
1-CSB-PA362073LD01HQD
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Biotin conjugated. Tested in the following application: ELISA

Genome Polyprotein (HCV-Core) Antibody
33487-05111 150 ug
EUR 261

Enterovirus 71 Genome polyprotein Antibody
20-abx109758
  • EUR 411.00
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Hepatitis C Genome polyprotein
1-CSB-RP184674Ba
  • EUR 611.00
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  • 200ug
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  • MW: 71.3 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli

Enterovirus 71 Genome polyprotein Antibody (FITC)
20-abx106801
  • EUR 411.00
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Enterovirus 71 Genome polyprotein Antibody (HRP)
20-abx108220
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
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  • 100 ug
  • 1 mg
  • 200 ug
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Enterovirus 71 Genome polyprotein Antibody (Biotin)
20-abx105382
  • EUR 411.00
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Genome Polyprotein Polyclonal Antibody, HRP Conjugated
A56131 100 µg
EUR 570.55
Description: The best epigenetics products

Genome Polyprotein Polyclonal Antibody, FITC Conjugated
A56132 100 µg
EUR 570.55
Description: kits suitable for this type of research

Genome Polyprotein Polyclonal Antibody, Biotin Conjugated
A56133 100 µg
EUR 570.55
Description: fast delivery possible

Genome Polyprotein Polyclonal Antibody, HRP Conjugated
A56744 100 µg
EUR 570.55
Description: The best epigenetics products

Genome Polyprotein Polyclonal Antibody, FITC Conjugated
A56745 100 µg
EUR 570.55
Description: kits suitable for this type of research

Genome Polyprotein Polyclonal Antibody, Biotin Conjugated
A56746 100 µg
EUR 570.55
Description: fast delivery possible

Genome Polyprotein Polyclonal Antibody, Biotin Conjugated
A68250 100 µg
EUR 570.55
Description: reagents widely cited

Genome Polyprotein Polyclonal Antibody, FITC Conjugated
A68251 100 µg
EUR 570.55
Description: Ask the seller for details

Genome Polyprotein Polyclonal Antibody, HRP Conjugated
A68252 100 µg
EUR 570.55
Description: The best epigenetics products

Genome Polyprotein Polyclonal Antibody, HRP Conjugated
A68255 100 µg
EUR 570.55
Description: Ask the seller for details

Genome Polyprotein Polyclonal Antibody, FITC Conjugated
A68256 100 µg
EUR 570.55
Description: The best epigenetics products

Genome Polyprotein Polyclonal Antibody, Biotin Conjugated
A68257 100 µg
EUR 570.55
Description: kits suitable for this type of research

Human rhinovirus 1A Genome polyprotein
1-CSB-YP326367HQA
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 34.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human rhinovirus 1A Genome polyprotein,partial expressed in Yeast

Japanese encephalitis virus Genome polyprotein
1-CSB-EP189574Ba
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 90.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Japanese encephalitis virus Genome polyprotein,partial expressed in E.coli

Yellow fever virus Genome polyprotein
1-CSB-EP365905YAC1
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 78.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Yellow fever virus Genome polyprotein,partial expressed in E.coli

Genome Polyprotein (HCV-Core) Antibody (Biotin Conjugate)
33487-05121 150 ug
EUR 369

Rhinovirus A serotype 89 Genome polyprotein Antibody
20-abx109372
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Genome Polyprotein (HCV-Core) AssayLite Antibody (FITC Conjugate)
33487-05141 150 ug
EUR 428

Genome Polyprotein (HCV-Core) AssayLite Antibody (RPE Conjugate)
33487-05151 150 ug
EUR 428

Genome Polyprotein (HCV-Core) AssayLite Antibody (APC Conjugate)
33487-05161 150 ug
EUR 428

Adaptation and validation of the Genetic Counseling Outcome Scale for autism spectrum disorders and related conditions

The genetics care pathway experienced by families affected by autism spectrum disorder (ASD) around the time of diagnosis is currently uncharacterized and potentially variable across contexts. The lack of consensus on outcome measures to capture the impact of genetic services for these families shows a gap in understanding and optimizing this genetics care pathway.
The Genetic Counseling Outcome Scale (GCOS-24) is a validated outcome measure of clinical genetics services. The current study aims to adapt and validate the GCOS-24 as an outcome measure in the context routine genetic testing in ASD and related conditions. Families seen for their child’s developmental evaluation for ASD and related conditions were invited to participate in a genomics cohort between 2016 and 2018. Families (n = 111) completed the mGCOS-24 (modified GCOS-24), adapted from the original GCOS-24 by clinicians working in the target population’s routine care pathway.
The mGCOS-24 has acceptable internal consistency (Cronbach’s α = 0.84) and high test-retest reliability (ICC = 0.88). It also inversely correlates with stress as measured by Perceived Stress Scale (PSS-10) and distress, as measured by the Distress Thermometer, rs ≥ 0.39, ps < 0.001. The mGCOS-24 had adequate readability, as supported by cognitive interviews completed by a sub-sample of five mothers of a child with ASD.
Together, our findings show that the mGCOS-24 has good validity for the target population. Preliminary characterization of the genetics care pathway in this population revealed remarkable variability in pre-test counseling and limited post-test counseling. The use of the mGCOS-24 as an outcome measure is useful in filling some of these gaps by offering a way to assess, and in the future, optimize the genetics care pathway for families affected by autism and related neurodevelopmental conditions.

Potential causes and consequences of rapid mitochondrial genome evolution in thermoacidophilic Galdieria (Rhodophyta)

  • Background: The Cyanidiophyceae is an early-diverged red algal class that thrives in extreme conditions around acidic hot springs. Although this lineage has been highlighted as a model for understanding the biology of extremophilic eukaryotes, little is known about the molecular evolution of their mitochondrial genomes (mitogenomes).
  • Results: To fill this knowledge gap, we sequenced five mitogenomes from representative clades of Cyanidiophyceae and identified two major groups, here referred to as Galdieria-type (G-type) and Cyanidium-type (C-type). G-type mitogenomes exhibit the following three features: (i) reduction in genome size and gene inventory, (ii) evolution of unique protein properties including charge, hydropathy, stability, amino acid composition, and protein size, and (iii) distinctive GC-content and skewness of nucleotides. Based on GC-skew-associated characteristics, we postulate that unidirectional DNA replication may have resulted in the rapid evolution of G-type mitogenomes.
  • Conclusions: The high divergence of G-type mitogenomes was likely driven by natural selection in the multiple extreme environments that Galdieria species inhabit combined with their highly flexible heterotrophic metabolism. We speculate that the interplay between mitogenome divergence and adaptation may help explain the dominance of Galdieria species in diverse extreme habitats.

PSMB8 Antibody
1-CSB-PA775839
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  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

PSMB8 antibody
22848-100ul 100ul
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PSMB8 Antibody
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PSMB8 Antibody
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Description: PSMB8 antibody detects endogenous levels of total PSMB8.

PSMB8 antibody
70R-19589 50 ul
EUR 435
Description: Rabbit polyclonal PSMB8 antibody

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EUR 457
Description: Affinity purified Rabbit polyclonal PSMB8 antibody

Anti-PSMB8 antibody
STJ29479 100 µl
EUR 277
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Anti-PSMB8 antibody
STJ11100809 100 µl
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Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

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C43134 100ul
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Psmb8/ Rat Psmb8 ELISA Kit
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PSMB8 siRNA
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pOTB7-PSMB8
PVT18497 2 ug
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PSMB8 Antibody, HRP conjugated
1-CSB-PA018886LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated
1-CSB-PA018886LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PSMB8 Antibody, Biotin conjugated
1-CSB-PA018886LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

PSMB8 Rabbit pAb
A7340-100ul 100 ul
EUR 308

PSMB8 Rabbit pAb
A7340-200ul 200 ul
EUR 459

PSMB8 Rabbit pAb
A7340-20ul 20 ul
EUR 183

PSMB8 Rabbit pAb
A7340-50ul 50 ul
EUR 223

PSMB8 Blocking Peptide
BF0434-BP 1mg
EUR 195

anti-PSMB8 (1A5)
LF-MA30618 100 ul
EUR 527
Description: Mouse Monoclonal to PSMB8

Anti-PSMB8 / LMP7 Monoclonal Antibody
M02188-2 100ug
EUR 397
Description: Rabbit Monoclonal PSMB8 / LMP7 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Monoclonal PSMB8 Antibody, Clone: 1A5
AMM02864G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Mouse PSMB8 shRNA Plasmid
20-abx971337
  • EUR 801.00
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  • 150 µg
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Rat PSMB8 shRNA Plasmid
20-abx984734
  • EUR 801.00
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Human PSMB8 shRNA Plasmid
20-abx953843
  • EUR 801.00
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Canine PSMB8 ELISA KIT
ELI-15651d 96 Tests
EUR 928

PSMB8 protein (His tag)
80R-2608 100 ug
EUR 322
Description: Purified recombinant PSMB8 protein

PSMB8 Recombinant Protein (Mouse)
RP165287 100 ug Ask for price

PSMB8 Recombinant Protein (Human)
RP085356 100 ug Ask for price

PSMB8 Recombinant Protein (Rat)
RP222629 100 ug Ask for price

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3
AMM03954G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx114776
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx141396
  • EUR 370.00
  • EUR 606.00
  • EUR 300.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
20-abx006453
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx011689-100ul 100 ul
EUR 411
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx028154-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Proteasome Subunit Beta Type-8 (PSMB8) Antibody
abx028154-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Proteasome subunit beta type-8 (PSMB8) Antibody
20-abx211178
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Proteasome subunit beta type-8 (PSMB8) Antibody
20-abx211851
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

[KO Validated] PSMB8 Rabbit pAb
A19933-100ul 100 ul
EUR 410

[KO Validated] PSMB8 Rabbit pAb
A19933-200ul 200 ul
EUR 571

[KO Validated] PSMB8 Rabbit pAb
A19933-20ul 20 ul
EUR 221

[KO Validated] PSMB8 Rabbit pAb
A19933-50ul 50 ul
EUR 287

PSMB8 ELISA Kit (Dog) (OKEH03975)
OKEH03975 96 Wells
EUR 844
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

PSMB8 ELISA Kit (Human) (OKCD02695)
OKCD02695 96 Wells
EUR 792
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

PSMB8 ELISA Kit (Human) (OKEH07770)
OKEH07770 96 Wells
EUR 1092
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

Psmb8 ORF Vector (Rat) (pORF)
ORF074211 1.0 ug DNA
EUR 506

PSMB8 ORF Vector (Human) (pORF)
ORF028453 1.0 ug DNA
EUR 405

Psmb8 ORF Vector (Mouse) (pORF)
ORF055097 1.0 ug DNA
EUR 506

PSMB8 sgRNA CRISPR Lentivector set (Human)
K1740301 3 x 1.0 ug
EUR 339

Psmb8 sgRNA CRISPR Lentivector set (Rat)
K6921501 3 x 1.0 ug
EUR 339

Psmb8 sgRNA CRISPR Lentivector set (Mouse)
K4425601 3 x 1.0 ug
EUR 339

Human Proteasome subunit beta type-8 (PSMB8)
1-CSB-EP018886HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 42.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1)
K1740302 1.0 ug DNA
EUR 154

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2)
K1740303 1.0 ug DNA
EUR 154

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3)
K1740304 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6921502 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6921503 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6921504 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4425602 1.0 ug DNA
EUR 154

PSMB8 3'UTR GFP Stable Cell Line
TU069046 1.0 ml
EUR 1394

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4425603 1.0 ug DNA
EUR 154

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4425604 1.0 ug DNA
EUR 154

PSMB8 Protein Vector (Rat) (pPB-C-His)
PV296842 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPB-N-His)
PV296843 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPM-C-HA)
PV296844 500 ng
EUR 603

PSMB8 Protein Vector (Rat) (pPM-C-His)
PV296845 500 ng
EUR 603

PSMB8 Protein Vector (Human) (pPB-C-His)
PV113810 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPB-N-His)
PV113811 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPM-C-HA)
PV113812 500 ng
EUR 552

PSMB8 Protein Vector (Human) (pPM-C-His)
PV113813 500 ng
EUR 552

Recombinant Human PSMB8 Protein, His, E.coli-1mg
QP13190-1mg 1mg
EUR 2757

Recombinant Human PSMB8 Protein, His, E.coli-20ug
QP13190-20ug 20ug
EUR 201

Recombinant Human PSMB8 Protein, His, E.coli-5ug
QP13190-5ug 5ug
EUR 155

PSMB8 Protein Vector (Mouse) (pPB-C-His)
PV220386 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPB-N-His)
PV220387 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPM-C-HA)
PV220388 500 ng
EUR 603

PSMB8 Protein Vector (Mouse) (pPM-C-His)
PV220389 500 ng
EUR 603

Psmb8 3'UTR Luciferase Stable Cell Line
TU216964 1.0 ml Ask for price

PSMB8 3'UTR Luciferase Stable Cell Line
TU019046 1.0 ml
EUR 1394

Psmb8 3'UTR GFP Stable Cell Line
TU266964 1.0 ml Ask for price

Psmb8 3'UTR Luciferase Stable Cell Line
TU117173 1.0 ml Ask for price

Psmb8 3'UTR GFP Stable Cell Line
TU167173 1.0 ml Ask for price

PSMB8 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
LV700471 1.0 ug DNA
EUR 514

PSMB8 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
LV700475 1.0 ug DNA
EUR 514

PSMB8 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
LV700476 1.0 ug DNA
EUR 514

PSMB8 Proteasome Subunit Beta Type 8 Human Recombinant Protein
PROTP28062 Regular: 20ug
EUR 317
Description: PSMB8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 229 amino acids (73-276 a.a.) and having a molecular mass of 25.4kDa. PSMB8 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Dog PSMB8/ Proteasome subunit beta type-8 ELISA Kit
E0091Do 1 Kit
EUR 717

Human PSMB8/ Proteasome subunit beta type-8 ELISA Kit
E2074Hu 1 Kit
EUR 605

Rat Psmb8/ Proteasome subunit beta type-8 ELISA Kit
E0811Ra 1 Kit
EUR 646

Mouse Psmb8/ Proteasome subunit beta type-8 ELISA Kit
E1218Mo 1 Kit
EUR 632

Monkey Low Molecular Mass Protein 7 (PSMB8) ELISA Kit
abx360252-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Pig Low Molecular Mass Protein 7 (PSMB8) ELISA Kit
abx361997-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rabbit Low Molecular Mass Protein 7 (PSMB8) ELISA Kit
abx362317-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Alec

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